Comparison of Dexmedetomidine and Fentanyl as Intrathecal adjuvants to 0.5% Hyperbaric Bupivacaine for Total Abdominal Hysterectomy under Subarachnoid Block

Abstract :

To compare the effects of intrathecal dexmedetomidine and fentanyl as adjuvants to hyperbaric bupivacaine regards to time of onset of sensory and motor blockade, Duration of sensory blockade and motor blockade, Two segment sensory regression time, Duration of effective postoperative analgesia and incidence of side effects. A randomized, prospective study, after obtaining ethical committee approval in K.A.P.V Government Medical College Hospital and written informed consent of patients was conducted on 60 Adult Patients of female sex, aged between 40 to 60 years, of physical status ASA Grade I and Grade II undergoing elective Total abdominal hysterectomy surgeries under spinal anaesthesia. Patients were divided into 2 groups of 30 each. Group D received 15mg hyperbaric bupivacaine with 10mcg dexmedetomidine in 0.5ml of normal saline. Group F received 15mg hyperbaric bupivacaine with 25mcg fentanyl. The time of onset of sensory and motor blockade and the duration of two segment sensory regression time, sensory, motor blockade and duration of effective post op analgesia was statistically significant in group D compared to group F. Intrathecal Dexmedetomidine is associated with faster onset of sensory and motor blockade, with significantly prolonged sensory and motor blockade and less requirement of rescue analgesia compared to fentanyl group.

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