PRP Application on Mid Dermal Burn Wound Healing in Wistar Rats

Abstract :

BackgroundPRP application was reported to help wound healing process in considerable amount of surgeries. This birthed the idea to apply PRP to burn wounds.PRP application helps wound healing by accelerating reepithelialization in wound area.Materials and MethodsA total of 40Wistar rats that met the inclusion and exclusion criteria were assigned to 2 random groups. Group 1 (platelet-rich plasma group) was exposed to burn injury and topical platelet-rich plasma was applied. Group 2 (control group) was exposed to burn injury and normal saline. Wound was measured macroscopically and compared on day 0, 3, 7 and 14. ResultsForty Wistar albino rats were divided into 2 groups of 20 rats each. Group 1 (platelet-rich plasma group) was exposed to burn injury and topical platelet-rich plasma was applied. Group 2 (control group) was exposed to burn injury only. A group of 20 Wistar rats were used as blood donors for platelet-rich plasma. The wound was measured on day 0, group 1 had an average burn area of 501,856 33,793 and group 2 had an average burn area of 482,532 35,242 (p = 0.085). On day 3, group 1 had an average burn area of 436,594 41,124 and group 2 had an average burn area of 482.908 41,410 (p = 0.001). On day 7, group 1 had an average burn area of 409,549 75,140 and group 2had an average burn area of 468,676 38,610 (p <0.001). On day 14, group 1 had an average burn area of 304,498 62,715 compared to group 2 with an average burn rate of 433,910 41,583. (p<0.001)ConclusionPRP improves wound healing time when measured macroscopically on multiple days compared to the controlled group. A further study on the histological aspect is needed to further understand the mechanism of the wound healing assisted by PRP.

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