The Effectiveness of Intravitreal Aflibercept in the Treatment of Neovascular Age-Related Macular Degeneration

Abstract :

PURPOSE:To evaluate the effectiveness of intravitreal aflibercept in neovascular age-related macular degeneration (AMD) patients followed in our clinic. METHOD:The examination file and optical coherence tomography (OCT) datas were investigated retrospectively.Patients divided into two groups according to previous therapies: patients received treatment before aflibercept (Group1) and started treatment with aflibercept (Group2).In Group2,patients were treated with pro-re-nata (PRN) regimen after 3 loading doses monthly.In Group1 patients were treated directly with PRN regimen after switching to aflibercept. RESULTS:154 eyes of 116 patients were enrolled. Average age of the patients were 75,2.The average follow-up duration was 39,01 months.The differences between the groups were statistically insignificant according to the sex,laterality of the eye and the post-aflibercept therapies (p>0,05).The number of aflibercept injections in Group2 was significantly higher than Group1 (p<0,05).VA changes both in the groups and between the groups were not significant in post-aflibercept and last visits,in comparison with the VA values before aflibercept injection (p>0,05).In Group1,central and average macular thickness in post-aflibercept and last visits were significantly thinner than pre-aflibercept visit (p<0,05).In Group2, the difference of central macular thickness values between pre and post-aflibercept visits was significant (p<0,05),however the difference between pre-aflibercept and last visits was not (p>0,05). In Group2, the average macular thickness values in both post-aflibercept and last visits were significantly thinner than the pre-aflibercept visit (p<0,05).Changes in macular thickness values between two groups were statistically insignificant (p>0,05). CONCLUSION:In treatment of neovascular AMD,intravitreal aflibercept is an effective method to avoid VA loss and to heal macular morphology.

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