International Journal Of Advances In Surgery
Aim : The aim is to study various clinicopathological features of Her2-neu enriched Breast cancer (HEBC) in Northern part of INDIA. Background:Molecular classification of east cancer is based on gene expressing profile.The subgroup [luminal A, luminal B, Her2-neu enriched Breast cancer (HEBC), and basal like] have distinct gene expression pattern and phenotypical characteristics.Her2-neu enriched Breast cancer (HEBC) tumors are of more aggressive variety, hence associated with poor prognosisHer2-neu enriched Breast cancer (HEBC) usually present with larger tumor size, more advanced tumor grade and TNM stage. The higher positive rate in lymph node metastasis is also observed..The pathological complete response (pCR) rate is consistently lower when compared with other subtypesMaterial And Method: Study Design: Hospital based retrospective, descriptive type of observational study. Study place: Dept. of general surgery SMS hospital Jaipur. Study population: 402 cases of diagnosed east cancer. Statistical Analysis: Descriptive statistics.Result: Total east cancer patients studied = 402 46 patients [11.44 %] were found to have Her2-neu enriched Breast cancer (HEBC) Maximum number of cases were in age group >50 years i.e. 27 (58.69 %). Most of the cases (32, 69.57 %) cases were postmenopausal. Her2-neu enriched Breast cancer (HEBC) cases [84.78 %] had histological features of IDCConclusions : Her2-neu enriched Breast cancer (HEBC) cases represents around 12 % of total east cancer. Her2-neu enriched Breast cancer (HEBC) cases is commonly associated with postmenopausal status, mostly seen in patient of age >50 years. Common mode of presentation is usually advanced disease i.e. T2 , N1 or more Her2-neu enriched Breast cancer (HEBC) cases most commonly have Grade III presentation.Her2-neu enriched Breast cancer (HEBC) cases most commonly occurs in UOQ and infiltrative duct carcinoma (IDC) is the most common histopathological variety.
CLINICOPATHOLOGICAL FEATURES OF HER2-NEU ENRICHED BREAST CANCER (HEBC) - A RETROSPECTIVE ANALYSIS, Dr. Pankaj Somani, Dr. Vinod jeengar, Dr. Saumya Somani, INTERNATIONAL JOURNAL OF ADVANCED MEDICINE : Volume-3 | Issue-6 | November-2019