Pure large neuroendocrine carcinoma (LCNEC) of the gallbladder is so rare that until now only 10 cases have been described. Herein we aimed to report a new case treated in the Salah Azaiez National Cancer Institute in Tunisia. We also reviewed the clinical features of all cases reported so far. We reported the case of a 67 years old men that had pure locally advanced LCNEC of the gallbladder, with posterior metastatic lymphadenopathy. He underwent a cholecystectomy followed by 6 cycles of Cisplatin and Etoposide chemotherapy, 3 cycles of gemcitabine and Capecitabine chemotherapy and a third line of metronomic Cyclophosphamide.
A PURE PRIMARY LARGE CELL NEUROENDOCRINE CARCINOMA OF THE GALLBLADDER, Amina Mokrani, Fatma Guermazi, Asma Gargoura, Wafa Koubaa, Yahyaoui Yosra, Feryel Letaief, Gabsi Azza, Meddeb Khedija, Ayadi Mouna, Chraiet Nesrine, Raies Henda, Mezlini Amel, INTERNATIONAL JOURNAL OF ADVANCED MEDICINE : Volume-2 | Issue-4 | July-2018