ijas
International Journal Of Advances In Surgery

ISSN (O) : 2663 - 046X

A CrossRef Indexed Journal

DOI : 10.34300/26630451

ISSN (P) : 2663 - 0451

IC VALUE : 92.22 (2019)

Volume : V, Issue : I, January - 2021


Original Research Paper

Chemokine CXCL-12 expression in Breast cancer and its association with lymphatic invasion and other prognostic markers

Ankur Agrawal, Mumtaz A. Ansari, Vivek Srivastava

Abstract :

Background: Search for prognostic marker in east cancer is an area of ongoing research. Lympho-vascular invasion (LVI) is an already established marker in predicting outcome in node negative east cancer patients. In various cancers, chemokine CXCL-12 has shown to have role in invasiveness and spread. Objective: To assess the expression of CXCL-12 in east cancer patients and its correlation with LVI. We also correlated the expression of CXCL-12 with other established clinico-pathological prognostic parameters.Methods: Prospectively 25 patients with histologically confirmed east cancer were included. Colour Doppler evaluation of east lump and axilla in terms of RI,PI and Vmax was done. Patients were categorized as having high or low CXCL12 on the basis of immunoreactive score. LVI was assessed H&E and IHC using D2-40. The CXCL-12 expression was correlated with LVI and also to Doppler parameters, tumour size, clinical lymph node status, number of positive lymph nodes, tumour grade, stage of disease and hormonal receptor status.Results: Nineteen out of 25 (76%) patients were CXCL12 positive. The CXCL12 positivity was significantly associated with tumour size (p=0.005), N stage (p = 0.002), clinical stage (p = 0.002), grade (p = 0.001) and number of positive lymph nodes (p<0.001). The CXCL12 positivity was significantly associated with RI and PI but not with Vmax. Fifteen patients (60%) showed LVI positivity on H&E staining while 13 patients (52%) were stained positive with D2-40. 13 (52%) patients were found to be having higher (>8.52) LMVD value than the mean value and rest were lower LMVD (n=12). The CXCL12 positive staining was found to be significantly associated with LVI both on H&E and D2-40 (p=0.013 and p=0.047 respectively).Conclusion: The results support the importance of CXCL12 assessment in east cancer as a surrogate marker for LVI and its potential for prognosis estimation.

Keywords :

Breast cancer, CXCL12, LMVD, LVI-D2-40


Cite This Article:

CHEMOKINE CXCL-12 EXPRESSION IN BREAST CANCER AND ITS ASSOCIATION WITH LYMPHATIC INVASION AND OTHER PROGNOSTIC MARKERS, Ankur Agrawal, Mumtaz A. Ansari, Vivek Srivastava, INTERNATIONAL JOURNAL OF ADVANCED MEDICINE : Volume-5 | Issue-1 | January-2021

References :


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